Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation-perfusion mismatch that can be characterized using subtraction computed tomography angiography sCTA.
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Methods: Triple-blinded, randomized, placebo-controlled trial was conducted in Chile in a tertiary-care hospital able to provide on-site sCTA scans and ventilatory support when needed between August and March In total, 82 eligible adults were admitted to the ED with RT-PCR-confirmed or highly probable SARS-COV-2 infection and sCTA performed within 24 h of admission showing perfusion abnormalities in areas of well-aerated lung parenchyma; 42 were excluded and 40 participants were enrolled and randomized ratio once hospitalized.
The active intervention group received sildenafil 25 mg orally three times a day for seven days , and the control group received identical placebo capsules in the same way. Secondary outcomes included admission to the ICU, requirement of non-invasive ventilation, invasive mechanical ventilation IMV , and mortality rates.
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Analysis was performed on an intention-to-treat basis. Results: Totally, 40 participants were enrolled 20 in the placebo group and 20 in the sildenafil group ; 33 [ Patients in the sildenafil arm showed a significantly shorter median length of hospital stay than the placebo group 9 IQR days vs. Conclusions: No statistically significant differences were found in the oxygenation parameters.
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A large-scale study is needed to confirm these results. Publication types Randomized Controlled Trial.
Substances Vasodilator Agents Sildenafil Citrate. Associated data ClinicalTrials.
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